Abstract:ObjectiveTo observe the functions of anticancer in vivo and the effects on chemotherapeutic drug of Shenchong granules.MethodsThe tumor inhibitory ratios and life elongation ratio of Shenchong granules on S180and H22 tumor bearing mice were observed. The effects of reducing toxicity and enhancing combination with cyclophosphamide(CTX) of Shenchong granules were also studied on S180-bearing mice. ResultsAt the dose of 2 g/kg,4 g/kg and 8 g/kg , the inhibitory ratios were18.05%,21.24% and 27.28% in S180bearing mice; 17.35%,20.34% and 27.26% in H22 bearing mice,respectively . With CTX in S180bearing mice,Shenchong granules could not only enhance the anti-tumor effects but also significantly relieve the decrease of the number of the peripheral white blood cell and bone marrow nucleated cells.ConclusionShenchong granules have some function of antitumor and obvious effects of efficacy enhancing and toxicity reducing by chemotherapy in mice.
Key words:Shenchong granules; S180; H22; Anti-tumor in vivo
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