Study on the Correlationship between Decoction Time, Administration Dose and the Efficacy of Resisting Inflammation and Relieving Pain of Prepared Sichuan Aconite Root
Abstract:ObjectiveTo investigate the correlationship between decoction time (DT), administration dose (AD) and the actions of resisting inflammation and relieving pain of Prepared Sichuan Aconite Root (PSAR ), confirm the best DT and AD of the PSAR acting.MethodsAccording to the efficacy of the PSAR dispelling wind and dampness and relieving pain, several animal models, including pain, inflammation models, uniform design (UD) and regression analysis were applied to confirm the best DT and AD of its different actions.ResultsThe PSAR obviously suppressed the mice's auricle swelling induced by xylene, reduced the number of mice's spraining body induced by acetic acid, increased their latencies of spraining body and stimulation of hot board, and improved their pain threshold value. The best DT and AD for the PSAR to resist inflammation and relieve pain were 6 hours and 2.4 g/kg respectively.ConclusionThe PSAR possesses evident actions of resisting inflammation and relieving pain, which are markedly correlated with the DT and AD. The best DT and AD for PSAR to resist inflammation and relieve pain are 6 hours and 2.4 g/kg respectively.