Abstract:ObjectiveThe aim was to observe the effect to IL6、TNFαof invigorating “Qi” , nourishing “Yin”, promoting blood circulation and dispersing phlegm method of TCM to insulin resistance(IR) in T2DM patients.MethodsThe selected patients were randomly divided into treatment group and control group ,each group has 20 patients. The treatment group patients took invigorating “Qi” , nourishing “Yin”, promoting blood circulation and dispersing phlegm formula, the control group patients took Rosiglitazone tablets.The BG , HbA1C, insulin, FINS,IL-6 and TNF-α between before treatment and after treatment were observed.IR was evaluated by FINS and ISI.ResultsThere was no statistic significance for each observed targets before treatment between the treatment group and the control groups (P>0.05). There was obvious significance after treatment compared with before treatment(P<0.01),and there was no statistic significance after treatment between the two groups (P>0.05).ConclusionInvigorating “Qi” , nourishing “Yin”, promoting blood circulation and dispersing phlegm method maybe improve IR by anti-inflammation.
[2]Hotamisligil GS,Budavari A,Murray DL,et a1.Reduced tyrosine kinase activitity of the insulin receptor in obesity-diabetes:Central role of tumor necrosis factor-a[J].J C lin Invest,1995,94:1543.
[3]Hotamisligfl GS,Arner P,Caro JF,et a1.Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance[J].J Clin Invest,1995,95 (5):2409.
[5]Solomon SS,Mishra SK,Cwik C,et a1.Pioglitazone and met.formin reverse insulin resistance induced by tumor necrosis factora1.phainfiver cells[J].Horm Metab Res,1997,29 (8):379.
[6]Hofmann C,Lorenz K,Braithwaite SS,et a1.Altered gene expression for tumor necrosis factor'alpha and its receptors during drug and dietary modulation of insulin resistance[J]. Endocrinology,1994,134(1):264.