The Longterm Toxicity Study of Fufang Cixian Granules on Rats
DENG Jiagang, WU Yuqiang, ZHEN Zuowen, ZHOU Zhi
1. Pharmaceutical Factory of Guangxi Traditional Chinese Medical University, Nanning 530023, China;
2.Guangxi Institute for Drug Control, Nanning 530021, China
Abstract:ObjectiveTo study the long- term toxicity of Fufang Cixian Granules on rats to provide some data for its clinical use. Methods80 rats were randomly divided into 4 groups, each group was given the extract of Fufang Cixian Granules intragastrically at doses of 0,58.0,29.0,14.5 g/kg for 6 weeks. The animals were observed for 2 weeks after medicine withdraw. Parameters were examined including general condition, bodyweight , blood cell, blood biochemistry, organ index, and histopathological exmination. ResultsNo toxic reaction was observed compared with control group. ConclusionFufang Cixian Granules should be safe in its clinical use with the recommended dosage.
Key words: Fufang Cixian Granules; Rats; Long term toxicity