The Protective Effect of Rhodiola sachalinesis (A.Bor) against Acute Liver Injury Induced by Acetaminophen(AAP) in Mice
Abstract:ObjectiveTo investigate the protective effect of Rhodiola sachalinensis(A.Bor) agaigt acute liver injury in mice induced by Acetaminophen(AAP) .Methods Administered the mice with 1 g/kg ethanol or water extraction of Rhodiola sachalinensis,1 h later,administered the mice with 1 g/kg ace taminophen(AAP),then observe the death rate.Administered the mice with different doses of ethanol or water extract of Rhodiola sachalinensis ,1 h later,administered the mice with the 0.5 g/kg Acetaminophen(AAP), then determinea the aspartate aminotransferase (AST) and alanine aminotransferase (ALT).Results80% of the group administered with 1 g/kg acetaminophen(AAP) were dead 24 h later, and death rate of the group that were administered with Rhodiola sachalinensis ethanol extraction or Rhodiola sachalinensis water extraction 1h in advance declined to 30% and 20%, meanwhile the serum enzymes of AST,ALT were reduced, with the same effect as Silymarin. ConclusionRhodiola sachalinensis(A.Bor) have certain protective effect against liver injury caused by acetaminophen(AAP).
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