The Protective Effects of Glyrrhizae on Smoking induced Pulmonary Injury in Mice
Abstract:ObjectiveTo investigate the protective effects of glycyrrhizae water-extraction on smoking-induced pulmonary injury in mice.MethodsKuming mice were randomly divided into 3 groups:healthy control group,model group and glycyrrhizae group. Except healthy control group,the others were exposed to cigarette smoke,qid,30 minute/day for 60 days. At the same time,the mouse of glycyrrhizae group were given glycyrrhizae water-extracion,bid for 60 days,the other mouse were given distilled water,bid for 60 days.The pathologic changes of airways and lung tissues were determined.The level of MDA and the activity of SOD were measured.ResultsThere were more chronic bronchites and emphysema in the model group than in the healthy control group. Cigarette smoking reduced the activity of SOD and increased MDA level.Compared with the model group,the pathologic injury of airways and lung tissues were reduced,the activity of SOD increased and the level of MDA decreased in glycyrrhizae group.ConclusionGlyrrhizae water-extract has the protective effect on smoking- induced injury.The mechanism may due to its antioxidation.