The Effects of Tetramethylprazine on Nephritic Morphology and Function of Immune Renal Injury in Rats
Abstract:ObjectiveTo study experimentally the effects of tetramethylprazine on nephritic morphology and function of immune renal injury in Rats.MethodsRats were administrated intra-abdominally fresh swine serum for 8 weeks to induce immune renal injury disease. Treated group was administrated intra-abdominally tetramethylprazine injection for 4 weeks. Hyperplasia of glomerulus basement membrane and the thickness of mesangium were determined under light microscope and by image analyzer, and it was tested for changes of the content of urinary protein(UP), maleic dialdehyde(MDA) and activity of superoxide dismutase(SOD).ResultsCompared with model group, the hyperplasia degree of mesangium and basement embrane were obviously inhibited, and the content of UP obviously decreased; MDA of serum was lowered and the serum SOD activity was markedly raised among rats of treating group(P<0.01).ConclusionTetramethylprazine can markedly improve the model rats' nephritic morphlology and function, eliminate proteinuria, raise the serum SOD activity and lower the content of serum MDA.