Abstract:ObjectiveTo study the antipyrectic effect of Guizhier Yuebiyi Tang.MethodsWistar rats were divided into four groups. Yeast was injected subtaneously to establish fever model. The antipyrectic effects of Guizhi Tang, Yuebi Tang, Guizhier Yuebiyi Tang were observed to confirm whether the effect of adding together, the coordination or oppressing the anti- relations exist in those herbs.ResultsGuizhi Tang, Yuebi Tang, and Guizhier Yuebiyi Tang had the antipyrectic effect in our study(P<0.05). And Guizhier Yuebiyi Tang had better effect than the others(P<0.05). There was no difference between Guizhi Tang and Yuebi Tang(P>0.05).ConclusionThe effect of the coordination and oppressing the anti- relations exist in these herbs.