Effect of Phenolic Alkaloids from Menispermun dauricum on Hemodynamics in Experimental Cerebral Ischemia
Abstract:ObjectiveTo investigate the effect of phenolic alkaloids from Menispermun dauricum (PAMD) on hemodynamics in rat and explore the mechanism of action for cerebral ischemia.MethodsThe external carotid artery of rat was ligated to observe the effect of PAMD on cerebral blood flow(CBF)、cerebral vascular resistance(CVR)、blood pressure(BP) and heart rate(HR).ResultsPAMD could increase CBF and decrease CVR,but had no effect of cardiac function.ConclusionPAMD pocesses protective action on cerebral ischemia and the mechanism of action is related to the increase of CBF and the decrease of CVR.Increase of CBF may be one of the protection mechanism