Study on the Chronic Toxicity of Total Extracts of Yexiazhu(TEY) in Beagle Dog
Abstract:ObjectiveTo observe the chronic toxicity of TEY in Beagle dog.MethodsRats of three experimental groups were i.g. TEY at dose of 1280 mg/(kg·d),640 mg/(kg·d)and 320 mg/(kg·d), respectively,6 days per week for 6 months.Rats of control group were given distilled water at the same volume.Growth of rats were observed.Indexes of hematology and blood biochemistry were measured.Ratio of viscera to body were measured and the major organs were examined by the pathology.All these tests were carried out three and six months after i.g. and one month after stopping i.g.ResultsThe outer appearance and behavior, weights, the indexes of hematology and blood biochemistry were normal. The organ coefficient, the cardiogram, the pathological examination had no significant difference by comparing with control group.ConclusionTEY has no significant toxicity for long - term administration to rats.
Key words:Total extracts of Yexiazhu (TEY) in beagle dog; Chronic toxicity in beagle dog