Study on Mutagenicity of Total Extracts of Yexiazhu(TEY)
Abstract:ObjectiveTo evaluate the mutagenicity of total extracts of Yexiazhu(TEY). MethodsThe micronucleus test in mice, Ames test and chromosome aberration test were carried out.ResultsThe micronucleus rates in all doses were not significantly different from the control group. No increase in the number of revertant colonies was found in the Ames test with and without S9 activation system. Negative results were seen from chromosome aberration test in CHL cell. ConclusionNo mutagenicity effects of TEY were detected in this study .
Key words:Total extracts of Yexiazhu; Mutagenicity; Micronucleus test in mice; Ames test; Chromosome aberration test