Protective Effects of Breviscapine on Cerebral Hypoxia in Mice
Abstract:ObjectiveTo study the protective effects of breviscapine on cerebral hypoxia in mice. MethodsThe protective effects on cerebral hypoxia were investigated on survival time after ip 200 mg/kg NaNO2 and gasping duration after decapitation in mice following 7d consecutive oral administration of breviscapine (10,20 mg/kg, ig). ResultsAdministration of breviscapine (10 mg/kg, ig) for 7 d could significantly prolong survival time after ip NaNO2 in mice.Compared with control group, the survival time after ip NaNO2 was prolonged 83.9 % and 4.93 %. Administration of breviscapine (10,20 mg/kg, ip) for 7d could significantly prolong gasping duration after decapitation in mice. The gasping duration after decapitation of the two experiment groups were found 1.60 and 1.30 times of the control group respectively. ConclusionBreviscapine has significant protective effects on cerebral hypoxia in mice.