Toxicological Test on Flavonoids from Leaves of Dendrocalamus Latiflorus
Abstract:ObjectiveAcute toxicity experiments and mutation experiments were conducted on mice with the flavonoids from the leaves of Dendrocalamus latiflorus.MethodsBy means of acute toxicity test, malformation test of mice sperm, micronucleus test of bone marrow cell and Ames test .ResultsLD50(ig) for mice was more than 25 g·(kg·bw)-1 and in LD50(ip) for mice was more than 10 g·(kg·bw)-1. Mutagenic action of flavonoid from bamboo leaves on TA97,TA98,TA100 and TA102,and toxic effect on mice marrow micronucleus as well as effect on malformation of mice sperm were all negative.ConclusionThe flavonoids from leaves of Dendrocalamus latiflorus was a type of secure function factor of healthy food,but whether it has toxic or negative effect on human or not it need further observation in clinical application.
Key words:Flavonoids from bamboo leaves(FBL); LD50;Ames experiment;Micronucleus;Mutation experiments; Toxicology
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